Coxbitor 200/Coxbitor 400 Warnings

Coxbitor 400: Absolute contraindications: Not to be given to those patients who have history of: Stroke: cerebrovascular accident, CVA; Heart attack: Myocardial Infarction, MI; Coronary artery bypass graft: CABG; Uncontrolled hypertension; Congestive heart failure (CHF) NYHA II-IV. COX-2 inhibitors are not to be given to patients with allergy to NSAIDs and those with asthma. Exercise caution when prescribing Selective COX-2 inhibitors in patients with ischemic heart disease and those with risk factors for heart disease; hypertension; hyperlipidaemia, diabetes, smoking and patients with peripheral arterial disease. Considering association between cardiovascular risk and exposure to COX-2 inhibitors, doctors are advised to use the lowest effective dose for the shortest duration of treatment.
Intake of COX-2 inhibitors should be stopped with appearance of skin rash and signs of hypersensitivity.
If not yet warning statement should include potential gastrointestinal (gastric and liver) and renal toxicities.